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Challenging taste: scientist find new protein for detecting flavours

Posted: 16 January 2018 | | No comments yet

Scientists have discovered a new protein linked to how humans taste, a potential tool in the fight against obesity and other health problems related to nutrition.

Taste

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In a challenge to current thinking regarding how humans taste, scientists in the US have discovered a new protein associated with detecting different flavours.

Until now, many believed that a single protein — TRPM5 — acted as a gatekeeper for tasting these delectable foods. Remove TRPM5 from a person’s taste cells, and they would no longer be able to identify sweet, bitter or savoury (also called umami) foods.

New research, published on January 8 in the Proceedings of the National Academy of Sciences (PNAS) Early Edition, finds that a second protein — TRPM4 — performs a similar role in the taste system.

In experiments, mice who had TRPM4 drank sugar water enthusiastically and enjoyed a savoury treat. They also recoiled from quinine, a bitter compound. Mice who were missing the protein on their taste cells had a more difficult time detecting sweet, bitter and savoury flavors.

“Our research shows that there is redundancy in the taste system,” said lead researcher Kathryn Medler, PhD, Associate Professor of Biological Sciences in the University at Buffalo College of Arts and Sciences. “This is important because taste is actually central to our survival. If you can’t taste something bitter, you might gobble up something that’s poisonous without ever knowing that it could be harmful.”

“Taste, in general, is one of our underappreciated senses,” she added.

Changing dogma in taste science

“Our study changes a central dogma in the field — that detecting bitter, sweet and umami stimuli is dependent on the presence of TRPM5 alone,” says Debarghya Dutta Banik, the study’s first author and a PhD candidate in biological sciences at the University at Buffalo. “This research helps us understand how the taste system works.”

Like TRPM5, TRPM4 is a special kind of protein called an ion channel. Found on taste cells, TRPM5 and TRPM4 channels open when sweet, bitter or savoury foods land on the tongue. This sets off a chain reaction in which the cells produce an electrical signal that travels to the brain, notifying the organ of which flavors have been detected.

Banik and Medler’s new study found that mice were most sensitive to sweet, bitter and umami stimuli when the animals had both TRPM5 and TRPM4 on their taste cells. Removing either protein caused a decrease in sensitivity, and removing both left the mice unable to detect the flavors at all.

Though the study was done on mice, the research is likely relevant to humans, Medler says. TRPM5 and TRPM4 are both present in human taste cells, and TRPM5 is known to play a role in how people taste.

In addition to Medler and Banik, the authors of the new PNAS study include graduate student Laura E. Martin and Assistant Professor Ann-Marie Torregrossa, both in the UB Department of Psychology, and Marc Freichel at Universitat Heidelberg in Germany.

Taste and human health

Medler and Banik say it’s important to study how humans detect flavour in part because it influences human health. It helps to regulate appetite, and may contribute to problems such as overeating and undereating.

In a 2013 study, Medler’s team found that the taste cells of overweight mice were less sensitive to sweets than the cells of slimmer counterparts. Medler says it’s possible that trouble detecting sweetness may lead obese mice to eat more to get the same payoff.

And in humans, a loss of appetite is a common problem among older adults. These same cells become less sensitive as people age, which can lead to a lack of interest in food, resulting in malnutrition and poor overall health.

“It’s important for us to understand how the taste system works,” Medler says. “The more we know, the easier it will be to find solutions to problems when the system isn’t working correctly.”

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