Study shows possible link between red meat and heart disease
Posted: 18 February 2016 | | No comments yet
Patients with acute heart failure often have high levels of a metabolite of which red meat is a major dietary source, according to a new study…
Red meat, which has been reported to be associated with cardiovascular disease, is a source of L-carnitine which is broken down by gut bacteria to form the metabolite trimethylamine N-oxide (TMAO).
The team, led by Professor Toru Suzuki, measured circulating TMAO levels in approximately 1,000 patients admitted to University Hospitals of Leicester NHS Trust with acute heart failure.
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The study was the first to investigate association of TMAO levels in acute heart failure patients, a condition associated with high mortality and morbidity – and suggests involvement of the gut microbiota and diet in outcomes of acute heart failure.
This study shows an association between circulating levels of a metabolite of this process with prognosis of acute heart failure.
Professor Suzuki said: “Patients with acute heart failure showed higher levels of the oxidised metabolite TMAO in those that died or had a repeat admission to hospital with heart failure within the first year.
“Our study shows that higher levels of TMAO, a metabolite of carnitine derived from red meat, is associated with poorer outcomes associated with acute heart failure, one of the main diseases of the heart.
“This metabolic pathway provides a possible link between how red meat is associated with heart disease.”