Keith Woelfel, Director of R&D at Caliper Foods, shares key insights into cannabis formulation studies and absorption rates to help manufacturers optimise their products.
The available consumer health benefits of cannabinoids are wide ranging – from pain and inflammation management to relaxation, mood and sleep assistance. Cannabinoids contain an array of compounds: the psychoactive delta 9 THC, non-psychoactive CBD, sleep-inducing CBN, energising THCV, to name just a few of the 113 identified types. All cannabinoids in their native state are fat-based, and (unfortunately) often poorly absorbed when ingested. If they are poorly absorbed, then consumers are less likely to reap the potential health benefits and this presents a challenge for manufacturers.
To answer this question, cutting-edge manufacturers are studying the pharmacokinetics of cannabinoids to understand the rate and amount of cannabinoid absorption when consumed, along with onset and duration times. Clinical research, conducted in humans across a multitude of commercial formulations, is shedding light on how well and how fast cannabinoid edible formulations are absorbed into the body. The primary finding is that converting cannabinoids from a lipid base to a water-based format drastically improves both absorption amount and rate. The secondary finding is that the ingredients and processes used to create the emulsion have a significant impact on their absorption profiles.
In a recent study, water-soluble CBD formulations increased blood absorption by as much as 434 percent over oil-based formulations. This absorption, or ‘area under the curve’ (AUC), generally occurs within four hours of consumption — the timeframe in which most consumers expect to reap any benefit. The water‑based formulations are significantly more effective at being absorbed within 10-45 minutes.
The current market’s lipid-based formulations didn’t achieve peak absorption until close to two hours (116 minutes), which is a long time to wait for a benefit. At 30 minutes post-consumption, CBD levels circulating in the blood steam were 990 percent greater in the water-soluble formulation versus the oil-based formulations. This means that the CBD in the water-soluble formulations is more likely to positively impact the endocannabinoid system throughout the body measurably faster and effectively provide the intended health benefits to consumers in a more predictable and dependable manner.
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Advertising & Targeting".
This cookie is set by GDPR Cookie Consent WordPress Plugin. The cookie is used to remember the user consent for the cookies under the category "Analytics".
This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Necessary".
This cookie is set by GDPR Cookie Consent WordPress Plugin. The cookie is used to remember the user consent for the cookies under the category "Performance".
This cookie is native to PHP applications. The cookie is used to store and identify a users' unique session ID for the purpose of managing user session on the website. The cookie is a session cookies and is deleted when all the browser windows are closed.
This session cookie is served by our membership/subscription system and controls whether you are able to see content which is only available to logged in users.
Analytics cookies collect information about your use of the content, and in combination with previously collected information, are used to measure, understand, and report on your usage of this website.
This cookie is set by LinkedIn. The purpose of the cookie is to enable LinkedIn functionalities on the page.
This cookie is set by YouTube and registers a unique ID for tracking users based on their geographical location
This cookie is set by LinkedIn and is used to store the language preferences of a user to serve up content in that stored language the next time user visit the website.
This cookie is set by LinkedIn and used for routing.
This cookie is set by LinkedIn share Buttons and ad tags.
We embed videos from our official Vimeo channel. When you press play, Vimeo will drop third party cookies to enable the video to play and to see how long a viewer has watched the video. This cookie does not track individuals.
This cookie is set by Spotler and tracks an anonymous visitor ID.
This cookie is set by Spotler and enables it to track the Load Balance Session Queue.
This cookie is set by Spotler to track the Internet Information Services (IIS) session state.
This cookie is set by Spotler and stores the UTM values for the session. UTM values are specific text strings that are appended to URLs that allow Communigator to track the URLs and the UTM values when they get clicked on.
This cookie is set by Google Analytics and is used to calculate visitor, session, campaign data and keep track of site usage for the site's analytics report. It stores information anonymously and assign a randomly generated number to identify unique visitors.
This cookies is set by Google Universal Analytics to throttle the request rate to limit the collection of data on high traffic sites.
This cookie is set by Google Analytics and is used to store information of how visitors use a website and helps in creating an analytics report of how the website is doing. The data collected including the number visitors, the source where they have come from, and the pages visited in an anonymous form.
Advertising and targeting cookies help us provide our visitors with relevant ads and marketing campaigns.
This cookie is set by Advanced Ads and measures the browser width.
This cookie is set by Advanced Ads and measures the number of previous page impressions.
This cookie is set by Advanced Ads and sets geo-location, user role and user capabilities. It is used by cache busting in Advanced Ads Pro when the appropriate visitor conditions are used.
This cookie is set by Advanced Ads and sets the referrer URL.
This cookie is a browser ID cookie set by LinkedIn share Buttons and ad tags.
This cookie is set by Google DoubleClick and stores information about how the user uses the website and any other advertisement before visiting the website. This is used to present users with ads that are relevant to them according to the user profile.
This cookie is set by LinkedIn and is used for tracking.
This cookie is set by Linkedin and is used to track visitors on multiple websites, in order to present relevant advertisement based on the visitor's preferences.
This cookie is set by YouTube. Used to track the information of the embedded YouTube videos on a website.
Performance cookies are includes cookies that deliver enhanced functionalities of the website, such as caching. These cookies do not store any personal information.
This cookie is set by Cloudflare content delivery network and, in conjunction with the cookie 'cf_use_ob', is used to determine whether it should continue serving “Always Online” until the cookie expires.
This cookie is set by Cloudflare content delivery network and is used to determine whether it should continue serving “Always Online” until the cookie expires.
This session cookie is served by our membership/subscription system and controls which types of content you are able to access.
This cookie is set by Litespeed Server and allows the server to store settings to help improve performance of the site.
This cookie is set by OneSignal push notifications and is used for storing user preferences in connection with their notification permission status.
This cookie is set by Youtube and is used to track the views of embedded videos.