Screening - Articles and news items
Issue 3 2013 • 19 June 2013 • Maarten Schutyser and Jimmy Perdana, Food Process Engineering Group, Wageningen UR, Martijn Fox, NIZO Food Research
Many food ingredients, such as enzymes and probiotics, are spray dried to provide a longer shelf life. A major hurdle when applying spray drying is the extensive optimisa tion required for formulation and drying conditions to obtain powders of acceptable quality. Therefore, a high-throughput screening platform based on single droplet drying mimicking spray drying was successfully developed. It allows, in combination with a novel viability enumeration technique, screening amongst others survival percentages of probiotic bacteria as a function of drying conditions and formulation…
Rapid and automated screening of priority β-agonists in urine using high resolution LC-MS technology
Issue 4 2011 • 6 September 2011 • Thorsten Bernsmann and Peter Fürst, Chemical and Veterinary Analytical Institute, and Michal Godula, Thermo Fisher Scientific
Beta-agonists (β-agonists) are synthetically produced compounds that are widely known for their bronchodilatory and tocolytic effects. At higher doses, these substances also have anabolic effects and can promote live weight gain in food producing animals. Clenbuterol is the most commonly used β-agonist for growth-promoting purposes, despite the fact that there have been documented cases when consumption of liver and meat from animals treated with clenbuterol has resulted in serious human intoxication1. Increased levels of β-agonists and their analogs have been associated with acute toxic effects such as heart palpitation, muscle tremor, tetany and severe migraines.
Due to their adverse effects, the use of β-agonists has been banned by the European Union and other regulatory agencies worldwide. Nevertheless, monitoring programmes have shown that β-agonists are still illegally used by food producers and moreover, newly developed analogs with modified structures are being continuously introduced in routine practice. As a result, there is a clear need for quick and simple screening methods to routinely and accurately monitor levels of β-agonists in samples of animal origin, including urine, plasma and tissues.
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