Leon Coulier - Articles and news items

Non-target multicomponent analytical surveillance of food contact materials

Issue 1 2009  •  20 February 2009  •  William D. van Dongen, Leon Coulier, Leo van Stee & Sander Koster, Analytical Research Department, TNO Quality of Life

Small organic molecules migrating from packaging or other food contact materials (FCM) may result in unwanted changes of the composition of the food. These molecules can be the ‘usual suspects’, i.e. starting materials (non-reacted monomers) and additives but also by-products, reaction products, impurities, degradation products of additives and conjugation products, also called non-intentionally added substances (NIAS). A recent example of NIAS originating from packaging materials is the migration of semicarbazide formed as a toxic decomposition product of azodicarbonamide used as a blowing agent for plastics. This example clearly shows that for safe packaging materials it is necessary to apply analytical methodologies and concepts that are capable to address the issue of unlisted substances.

New analytical approaches to investigate the fate of bisphenol A diglycidyl ether (BADGE) in foods

Issue 4 2008  •  3 December 2008  •  Leon Coulier & William van Dongen, TNO Quality of Life and Emma Bradley & Laurence Castle Central Science Laboratory, York

Many new developments in analytical chemistry are driven by needs for life science applications. Examples are the various –omics technologies, i.e. genomics, transcriptomics, proteomics and metabolomics and the use of isotope labelling. Food analysis is often thought to be less complex when one thinks of the determination of specific contaminants or nutrients in food, for example. However, there are cases when highly advanced analytical technologies are necessary.


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